Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

238

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P16444 (Created: 1990-08-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

DPEP1_HUMAN

Protein Name

Dipeptidase 1

Gene

DPEP1

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

411

Protein Mass [Da]

45674

Features

TypeDescriptionStatusStartEnd
signal peptide         1   16
chain   Dipeptidase 1      17   385
disulfide bond         87   170
disulfide bond         242   274
disulfide bond   Interchain      377   377
glycosylation site   N-linked (GlcNAc...)      57   57
glycosylation site   N-linked (GlcNAc...)   potential   279   279
glycosylation site   N-linked (GlcNAc...)      332   332
glycosylation site   N-linked (GlcNAc...)   potential   358   358
sequence variant   (in a colorectal cancer sample; somatic mutation)      0   0
strand         32   37
strand         63   65
strand         76   83
strand         116   118
strand         134   141
strand         161   166
strand         168   170
strand         188   192
strand         209   211
strand         262   265
strand         274   276
strand         299   301
strand         375   377
helix         18   27
helix         39   47
helix         54   56
helix         68   73
helix         87   89
helix         94   111
helix         122   130
helix         143   145
helix         150   158
helix         178   180
helix         194   206
helix         217   226
helix         250   259
helix         269   272
helix         280   293
helix         296   298
helix         321   330
helix         335   342
helix         344   355
helix         370   372
propeptide   Removed in mature form      386   411
metal ion-binding site   Zinc 1; catalytic      36   36
metal ion-binding site   Zinc 1; catalytic      38   38
metal ion-binding site   Zinc 2; catalytic      141   141
metal ion-binding site   Zinc 1; catalytic      141   141
metal ion-binding site   Zinc 2; catalytic      214   214
metal ion-binding site   Zinc 2; catalytic      235   235
binding site   Substrate      168   168
binding site   Substrate      246   246
binding site   Substrate      304   304
lipid moiety-binding region   GPI-anchor amidated serine      385   385
mutagenesis site   Partial loss of activity      0   0
mutagenesis site   Complete loss of activity      0   0
turn         58   60
turn         90   93
turn         113   115
turn         146   148
turn         181   183
turn         239   241
turn         305   307

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MWSGWWLWPLVAVCTA

Sequence

MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNR
LQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLE
QMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSL
GVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVV
KELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPD
DVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVG
FGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVF
EAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLAS
LAPLVLCLSLL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website