Signal Peptide Database - Mammalia

 Entry Details
ID   22229
Source Database   UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number   P02768    (Created: 1986-07-21 Updated: 2009-01-20)
UniProtKB/Swiss-Prot Entry Name   ALBU_HUMAN
Protein Name   Serum albumin
Gene   ALB
Organism Scientific   Homo sapiens
Organism Common   Human
Lineage   Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo
Protein Length [aa]   609
Protein Mass [Da]   69367
Features  
TypeDescriptionStatusStartEnd
signal peptide         1   18
chain   Serum albumin      25   609
disulfide bond         77   86
disulfide bond         99   115
disulfide bond         114   125
disulfide bond         148   193
disulfide bond         192   201
disulfide bond         224   270
disulfide bond         269   277
disulfide bond         289   303
disulfide bond         302   313
disulfide bond         340   385
disulfide bond         384   393
disulfide bond         416   462
disulfide bond         461   472
disulfide bond         485   501
disulfide bond         500   511
disulfide bond         538   583
disulfide bond         582   591
domain   Albumin 1      25   205
domain   Albumin 2      212   397
domain   Albumin 3      404   595
modified residue   Phosphoserine      82   82
modified residue   Phosphotyrosine      108   108
modified residue   Phosphotyrosine      164   164
glycosylation site   N-linked (Glc) (glycation)   probable   36   36
glycosylation site   N-linked (Glc) (glycation); in vitro      75   75
glycosylation site   N-linked (Glc) (glycation); in vitro      161   161
glycosylation site   N-linked (Glc) (glycation); in vitro      186   186
glycosylation site   N-linked (Glc) (glycation); in vitro      223   223
glycosylation site   N-linked (Glc) (glycation); in vitro      249   249
glycosylation site   N-linked (Glc) (glycation)   probable   257   257
glycosylation site   N-linked (Glc) (glycation); in vitro      300   300
glycosylation site   N-linked (Glc) (glycation)      305   305
glycosylation site   N-linked (Glc) (glycation); in vitro      337   337
glycosylation site   N-linked (Glc) (glycation)   probable   341   341
glycosylation site   N-linked (GlcNAc...); in variant Redhill      342   342
glycosylation site   N-linked (Glc) (glycation); in vitro      347   347
glycosylation site   N-linked (Glc) (glycation)   probable   375   375
glycosylation site   N-linked (Glc) (glycation); in vitro      402   402
glycosylation site   N-linked (Glc) (glycation); in vitro      437   437
glycosylation site   N-linked (Glc) (glycation)      463   463
glycosylation site   N-linked (Glc) (glycation); in vitro      468   468
glycosylation site   N-linked (GlcNAc...); in variant Casebrook      518   518
glycosylation site   N-linked (Glc) (glycation)      549   549
glycosylation site   N-linked (Glc) (glycation)   probable   558   558
glycosylation site   N-linked (Glc) (glycation); in vitro      560   560
glycosylation site   N-linked (Glc) (glycation); in vitro      569   569
glycosylation site   N-linked (Glc) (glycation); in vitro      597   597
sequence variant   (in Nagoya)      0   0
sequence variant   (in Christchurch/Honolulu-2)      0   0
sequence variant   (in Herborn)      0   0
sequence variant   (in Nagasaki-3)      0   0
sequence variant   (in dbSNP:rs3210154)      0   0
sequence variant   (in Takefu/Honolulu-1)      0   0
sequence variant   (in Redhill/Malmo-I/Tradate; associated with T-344 in Redhill)      0   0
sequence variant   (in Hawkes bay)      0   0
sequence variant   (in Tregasio)      0   0
sequence variant   (in Komagome-2)      0   0
sequence variant   (in FDH)      0   0
sequence variant   (in Tradate-2)      0   0
sequence variant   (in Larino)      0   0
sequence variant   (in Jaffna)      0   0
sequence variant   (in Yanomama-2)      0   0
sequence variant         0   0
sequence variant   (in Vibo Valentia)      0   0
sequence variant   (in FDH)      0   0
sequence variant   (in Malmo-95/Dalakarlia)      0   0
sequence variant   (in Torino)      0   0
sequence variant   (in dbSNP:rs3210163)      0   0
sequence variant         0   0
sequence variant   (in dbSNP:rs3204504)      0   0
sequence variant   (in Malmo-10)      0   0
sequence variant   (in Fukuoka-2/Lille/Taipei/Varese/ Komagome-3)      0   0
sequence variant   (in FDH)      0   0
sequence variant   (in Kenitra)      0   0
sequence variant   (in Maddaloni)      0   0
sequence variant   (in Ortonovo)      0   0
sequence variant   (in Manaus-1/Adana/Lambadi/ Vancouver)      0   0
sequence variant   (in Casebrook)      0   0
sequence variant   (in Dublin)      0   0
sequence variant   (in Bleinheim/Iowa city-2)      0   0
sequence variant   (in dbSNP:rs1063469)      0   0
sequence variant   (in Liprizzi)      0   0
sequence variant   (in Castel di Sangro)      0   0
sequence variant   (in Maku)      0   0
sequence variant   (in Vanves)      0   0
sequence variant   (in Gent/Milano Fast)      0   0
sequence variant   (in Venezia)      0   0
sequence variant   (in Osaka-2/Phnom Phen/albumin B/ Verona)      0   0
sequence variant   (in Osaka-1)      0   0
sequence variant   (in Fukuoka-1/Paris-2)      0   0
sequence variant   (in Mexico)      0   0
sequence variant   (in Malmo-61)      0   0
sequence variant         0   0
sequence variant   (in Hiroshima-2)      0   0
sequence variant   (in Redhill; associated with C- 23)      0   0
sequence variant   (in Malmo-47)      0   0
sequence variant   (in Brest)      0   0
sequence variant   (in Bergamo)      0   0
sequence variant   (in Caserta)      0   0
sequence variant   (in Nagasaki-1)      0   0
sequence variant   (in Church bay)      0   0
sequence variant   (in Canterbury/New Guinea/ Tagliacozzo/Cuneo/Cooperstown)      0   0
sequence variant   (in Roma)      0   0
sequence variant   (in Sondrio)      0   0
sequence variant   (in Hiroshima-1)      0   0
sequence variant   (in Malmo-5)      0   0
sequence variant   (in Tochigi)      0   0
sequence variant   (in Nagasaki-2)      0   0
sequence variant   (in Naskapi/Mersin/Komagome-1)      0   0
sequence variant   (in Iowa city-1)      0   0
sequence variant   (in Parklands)      0   0
sequence variant   (in Trieste)      0   0
sequence variant   (in Coari I/Porto Alegre)      0   0
strand         83   85
strand         195   197
strand         561   563
helix         31   54
helix         60   79
helix         90   102
helix         105   108
helix         111   115
helix         124   128
helix         144   153
helix         155   167
helix         175   192
helix         198   230
helix         232   246
helix         252   271
helix         274   290
helix         292   295
helix         300   303
helix         307   314
helix         330   333
helix         339   345
helix         347   360
helix         367   385
helix         390   393
helix         394   397
helix         398   438
helix         444   461
helix         466   490
helix         495   503
helix         508   514
helix         528   530
helix         535   539
helix         542   559
helix         567   584
helix         591   605
site   Not glycated      28   28
site   Not glycated      44   44
site   Not glycated      65   65
site   Not glycated      88   88
site   Not glycated      97   97
site   Not glycated      117   117
site   Not glycated      130   130
site   Not glycated      160   160
site   Not glycated      183   183
site   Not glycated      198   198
site   Not glycated      205   205
site   Not glycated      214   214
site   Not glycated      219   219
site   Aspirin-acetylated lysine      223   223
site   Not glycated      229   229
site   Not glycated      236   236
site   Not glycated      264   264
site   Not glycated      286   286
site   Not glycated      298   298
site   Not glycated      310   310
site   Not glycated      383   383
site   Not glycated      396   396
site   Not glycated      413   413
site   Not glycated      426   426
site   Not glycated      438   438
site   Not glycated      456   456
site   Not glycated      460   460
site   Not glycated      490   490
site   Not glycated      499   499
site   Not glycated      524   524
site   Not glycated      543   543
site   Not glycated      548   548
site   Not glycated      562   562
site   Not glycated      565   565
site   Not glycated      581   581
site   Not glycated      584   584
site   Not glycated      588   588
site   Not glycated      598   598
splice variant   (in isoform 2)      43   234
propeptide         19   24
metal ion-binding site   Copper   by similarity   27   27
binding site   Bilirubin   potential   264   264
turn         119   123
SP Length   18
 ----+----1----+----2----+----3----+----4----+----5
Signal Peptide MKWVTFISLLFLFSSAYS
Sequence MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA
FAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCT
VATLRETYGEMADCCAKQ
EPERNECFLQHKDDNPNLPRLVRPEVDVMCTA
FHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAA
CLLPKLDELRDEGKASSAKQRLKCASLQKFGERA
FKAWAVARLSQRFPKA
E
FAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECC
EKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVF
LGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDE
FKPLVEEPQNLI
KQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEV
SRNLG
KVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKC
CTE
SLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQ
TALVELVKH
KPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQA
ALGL
Original MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA
FAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCT
VATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTA
FHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAA
CLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKA
EFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVF
LGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDE
FKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEV
SRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKC
CTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQ
TALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
 ----+----1----+----2----+----3----+----4----+----5
Hydropathies  
 

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