Signal Peptide Database - Mammalia

 Entry Details
ID   182
Source Database   UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number   Q00495    (Created: 1993-04-01 Updated: 2009-01-20)
UniProtKB/Swiss-Prot Entry Name   CSF1R_RAT
Protein Name   Macrophage colony-stimulating factor 1 receptor
Gene   Csf1r
Organism Scientific   Rattus norvegicus
Organism Common   Rat
Lineage   Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Glires
                    Rodentia
                      Sciurognathi
                        Muroidea
                          Muridae
                            Murinae
                              Rattus
Protein Length [aa]   978
Protein Mass [Da]   109264
Features  
TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   19
chain   Macrophage colony-stimulating factor 1 receptor      20   978
disulfide bond      potential   42   84
disulfide bond      potential   127   177
disulfide bond      potential   224   278
disulfide bond      potential   417   483
transmembrane region      potential   512   536
topological domain   Extracellular   potential   20   511
topological domain   Cytoplasmic   potential   537   978
domain   Ig-like C2-type 1      24   104
domain   Ig-like C2-type 2      107   197
domain   Ig-like C2-type 3      204   298
domain   Ig-like C2-type 4      299   397
domain   Ig-like C2-type 5      398   503
domain   Protein kinase      580   914
modified residue   Phosphotyrosine   by similarity   554   554
modified residue   Phosphothreonine   by similarity   560   560
modified residue   Phosphothreonine   by similarity   565   565
modified residue   Phosphotyrosine; by autocatalysis   by similarity   697   697
modified residue   Phosphotyrosine; by autocatalysis   by similarity   706   706
modified residue   Phosphotyrosine; by autocatalysis   by similarity   807   807
glycosylation site   N-linked (GlcNAc...)   potential   45   45
glycosylation site   N-linked (GlcNAc...)   potential   73   73
glycosylation site   N-linked (GlcNAc...)   potential   302   302
glycosylation site   N-linked (GlcNAc...)   potential   335   335
glycosylation site   N-linked (GlcNAc...)   potential   389   389
glycosylation site   N-linked (GlcNAc...)   potential   410   410
glycosylation site   N-linked (GlcNAc...)   potential   449   449
glycosylation site   N-linked (GlcNAc...)   potential   478   478
glycosylation site   N-linked (GlcNAc...)   potential   491   491
active site   Proton acceptor   by similarity   776   776
binding site   ATP   by similarity   614   614
nucleotide phosphate-binding region   ATP   by similarity   586   594
SP Length   19
 ----+----1----+----2----+----3----+----4----+----5
Signal Peptide MELGPPLVLLLATVWHGQG
Sequence MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEW
DGPISPYWTLDPESPGSTLTTR
NATFKNTGTYRCTELEDPMAGSTTIHLY
VKDP
AHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLR
KTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNR
VHP
EPP
QIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNS
DFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVES
AY
L
NLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLE
FITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWN
NLTFELTLRYPP
EVSVTWMPV
NGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWND
THPEVLSQKPFDKVIIQSQLPIGTLKH
NMTYFCKTHNSVGNSSQYFRAVS
LGQ
SKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKI
IER
YEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAV
KMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA
CTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSS
YKNI
HLEKK
YVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLEL
WDLLHFSSQVAQGMAFLASKNCIHR
DVAARNVLLTSGHVAKIGDFGLARD
IMNDSN
YVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLG
LNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARL
ERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEE
SSSEHLACCEPGDIAQPLLQPNNYQFAC
Original MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEW
DGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLY
VKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLR
KTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHP
EPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNS
DFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLE
FITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPP
EVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWND
THPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVS
LGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKI
IERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA
CTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNI
HLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLEL
WDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARD
IMNDSNYVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLG
LNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEE
SSSEHLACCEPGDIAQPLLQPNNYQFAC
 ----+----1----+----2----+----3----+----4----+----5
Hydropathies  
 

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