Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

159

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P12111 (Created: 1989-10-01 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

CO6A3_HUMAN

Protein Name

Collagen alpha-3(VI) chain

Gene

COL6A3

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

3177

Protein Mass [Da]

343665

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   25
chain   Collagen alpha-3(VI) chain      26   3177
disulfide bond   Interchain   by similarity   2087   2087
disulfide bond      by similarity   3112   3162
disulfide bond      by similarity   3121   3145
disulfide bond      by similarity   3137   3158
domain   VWFA 1      39   213
domain   VWFA 2      242   419
domain   VWFA 3      445   620
domain   VWFA 4      639   816
domain   VWFA 5      837   1009
domain   VWFA 6      1029   1205
domain   VWFA 7      1233   1404
domain   VWFA 8      1436   1609
domain   VWFA 9      1639   1812
domain   VWFA 10      1838   2024
domain   Collagen-like 1      2038   2097
domain   Collagen-like 2      2104   2163
domain   Collagen-like 3      2174   2233
domain   Collagen-like 4      2249   2300
domain   Collagen-like 5      2314   2373
domain   VWFA 11      2402   2581
domain   VWFA 12      2619   2815
domain   Fibronectin type-III      2988   3076
domain   BPTI/Kunitz inhibitor      3112   3162
region of interest   Nonhelical region      26   2038
region of interest   Triple-helical region      2039   2375
region of interest   Nonhelical region      2376   3177
modified residue   Pyrrolidone carboxylic acid   probable   26   26
modified residue   4-hydroxyproline      2100   2100
modified residue   5-hydroxylysine      2103   2103
modified residue   4-hydroxyproline      2206   2206
modified residue   5-hydroxylysine      2209   2209
modified residue   5-hydroxylysine      2212   2212
modified residue   4-hydroxyproline      2239   2239
modified residue   4-hydroxyproline      2316   2316
modified residue   4-hydroxyproline      2319   2319
modified residue   5-hydroxylysine      2322   2322
modified residue   5-hydroxylysine      2337   2337
glycosylation site   N-linked (GlcNAc...)   potential   108   108
glycosylation site   N-linked (GlcNAc...)   potential   116   116
glycosylation site   N-linked (GlcNAc...)   potential   202   202
glycosylation site   N-linked (GlcNAc...)   potential   251   251
glycosylation site   N-linked (GlcNAc...)   potential   2079   2079
glycosylation site   O-linked (Gal...)      2103   2103
glycosylation site   O-linked (Gal...)      2209   2209
glycosylation site   O-linked (Gal...)      2212   2212
glycosylation site   O-linked (Gal...)      2322   2322
glycosylation site   N-linked (GlcNAc...)   potential   2331   2331
glycosylation site   O-linked (Gal...)      2337   2337
glycosylation site   N-linked (GlcNAc...)   potential   2558   2558
glycosylation site   N-linked (GlcNAc...)      2677   2677
glycosylation site   N-linked (GlcNAc...)   potential   2861   2861
glycosylation site   N-linked (GlcNAc...)   potential   3037   3037
sequence variant   (in dbSNP:rs11690358)      0   0
sequence variant   (in dbSNP:rs6728818)      0   0
sequence variant   (in dbSNP:rs36104025)      0   0
sequence variant   (in dbSNP:rs35848091)      0   0
sequence variant   (in dbSNP:rs36117715)      0   0
sequence variant   (in BM)      0   0
sequence variant   (in dbSNP:rs11896521)      0   0
sequence variant   (in dbSNP:rs9630964)      0   0
sequence variant   (in dbSNP:rs36092870)      0   0
sequence variant   (in dbSNP:rs34741387)      0   0
sequence variant   (in dbSNP:rs2270669)      0   0
sequence variant   (in dbSNP:rs1131296)      0   0
strand         3120   3122
strand         3125   3131
strand         3136   3142
strand         3144   3146
strand         3152   3154
helix         3110   3113
helix         3155   3162
repeat   LRR 1      63   85
repeat   LRR 2      152   175
repeat   LRR 3      256   279
repeat   LRR 4      469   492
repeat   LRR 5      589   610
repeat   LRR 6      663   690
repeat   LRR 7      703   729
repeat   LRR 8      792   815
repeat   LRR 9      1052   1075
repeat   LRR 10      1299   1326
repeat   LRR 11      1500   1524
repeat   LRR 12      1583   1611
repeat   LRR 13      1690   1713
repeat   LRR 14      1988   2013
repeat   LRR 15      2523   2548
repeat   LRR 16      2549   2576
site   Reactive bond      3122   3123
splice variant   (in isoform 2)      31   236
compositionally biased region   Thr-rich      2863   2898
compositionally biased region   Ala-rich      2908   2983
short sequence motif   Cell attachment site      2040   2042
short sequence motif   Cell attachment site      2136   2138
short sequence motif   Cell attachment site      2148   2150
short sequence motif   Cell attachment site      2154   2156
short sequence motif   Cell attachment site      2370   2372
turn         3132   3135

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRKHRHLPLVAVFCLFLSGFPTTHA

Sequence

MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTI
GEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQ
EVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLT
DGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFNL
ENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQDSADIIFLIDGS
NNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS
TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVL
VLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVF
TVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLV
DGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFN
THPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIP
KLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS
LVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANV
GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKS
DILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLL
TAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMD
DFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVG
QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL
NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG
RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLP
KIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEF
VQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTL
LGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN
PSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQV
ISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQY
VRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQ
RLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDD
EVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSL
EQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPD
GFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVL
DAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGG
KSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFR
ELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINF
RRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKR
QIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVI
TGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVG
NVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSRDQN
VFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEA
FDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVIH
FTDGADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGF
MYDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGQRGDRGPIGSIG
PKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFP
GEKGEVGEIGLDGLDGEDGDKGLPGSSGEKGNPGRRGDKGPRGEKGERGD
VGIRGDPGNPGQDSQERGPKGETGDLGPMGVPGRDGVPGGPGETGKNGGF
GRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGLIGEQGISGP
RGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDG
VGSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRRGNSGPPG
IVGQKGDPGYPGPAGPKGNRGDSIDQCALIQSIKDKCPCCYGPLECPVFP
TELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTY
NNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK
RVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQ
LINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFG
SWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLD
MSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD
FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQ
QLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDK
STELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQCDWFQGDQPTKNLVK
FGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKPVTII
NQPSVKPAAAKPAPAKPVAAKPVATKTATVRPPVAVKPATAAKPVAAKPA
AVRPPAAAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEI
TENSAKLHWERPEPPGPYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLA
GQTYHVAVVCYLRSQVRATYHGSFSTKKSQPPPPQPARSASSSTINLMVS
TEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNEN
KFGSQKECEKVCAPVLAKPGVISVMGT

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website